Operant Conditioning Ongoing Studies

Ongoing Studies

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Characterization of Physiological Changes Induced Through MEP Conditioning in People with SCI

R01 NS114279   NIH/National Institute of Neurological Disorders and Stroke (NINDS)

ClinicalTrials.gov ID: NCT04286191

The goal is to determine how MEP (motor evoked potential) conditioning induces cortical and corticospinal plasticity and how such plasticity changes locomotion in people with incomplete SCI will illuminate the dynamic process of inducing and shaping functionally relevant CNS multi-site plasticity through guiding targeted plasticity.

Spinal reflex Conditioning System for Enhancing Motor Function Recovery after Incomplete Spinal Cord Injury

U44 NS114420 NIH/ National Institute of Neurological Disorders and Stroke (NINDS)

ClinicalTrials.gov ID: NCT05094362

The goal is to validate the effectiveness of the new reflex operant conditioning system.

Can increasing MEP size improve upper extremity motor function in individuals with SCI?

A22-0037-001 Neilsen Foundation Allied Health Professional Research Award of ASIA

ClinicalTrials.gov ID: NCT05321017

The objectives of this project are to characterize the relationship between measures of corticospinal excitability and clinical measures of UE function, activity, and quality of life, and to obtain preliminary data on whether increasing MEP size in a key UE muscle through operant up-conditioning can improve UE motor function in individuals with SCI.

Targeted Spinal Cord Plasticity for Alleviating SCI-Related Neuropathic Pain

SC210118   Department of Defense / Congressionally Directed Medical Research Programs (CDMRP)

ClinicalTrials.gov ID: NCT05492188

The goal of this project is to decrease neural transmission in spinal pain pathways that become overactive after spinal cord injury (SCI) and contribute to the persistent SCI-related neuropathic pain (SCI-NP). To accomplish this, we will develop a non-invasive, non-pharmacological neurobehavioral training approach, through which people with SCI-NP learn to restore an appropriate balance of pain and non-pain-related spinal neural transmission through operant conditioning.